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문초희 ( Moon Cho-Hee ) - 가톨릭대학교 의과대학 성모병원
연보라 ( Yeon Bo-Ra ) - 가톨릭대학교 의과대학 성모병원
김현진 ( Kim Hyun-Jin ) - 가톨릭대학교 의과대학 성모병원
은방희 ( Eun Bang-Hee ) - 가톨릭대학교 의과대학 성모병원
배영이 ( Bae Young-Lee ) - 가톨릭대학교 의과대학 성모병원
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Abstract
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Purpose: The purpose of this study was to compare the efficacy of heparin flushing and normal saline flushing in maintaining patency of central venous catheters(CVCs), and to investigate relative risk factors of CVCs’ occlusion.
Method: A total of 159 patients who had been inserted with CVCs were included in the department of hemato-oncology of S hospital. The heparin group consisted of 74 patients with 10u/ml diluted heparin flushing from 23 November 2004 to 15 January 2005, and the normal saline group consisted of 85 patients with 0.9% normal saline flushing from 19 January to 31 March of 2005.
Result: The heparin group was significantly different from the normal saline group in CVCs’ occlusion. The normal saline group offered a much longer survival duration of CVCs’ patency than the heparin group. Potential bleeding signs (PT, aPTT) had no significant differences. In multivariate analysis, 0.9% normal saline (hazard ratio 0.50), chemo port (hazard ratio 3.38), and no administration of TPN (hazard ratio 0.25) were the significant factors for occlusion of CVCs.
Conclusion: For maintaining the patency of CVCs, 0.9% normal saline flushing are expected to be effective in reducing drug incompatibilities, lessening the bleeding tendency and improving cost effectiveness.
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KeyWords
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중심정맥 카테터, 헤파린 관류, 생리식염수 관류
Central Venous Catheter, Heparin Flushing, Normal Saline Flushing
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원문 및 링크아웃 정보
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등재저널 정보
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